Lactobacillus
Reuteri
Lactobacillus reuteri is a type of probiotic
bacteria that is found in the gut flora of some
mammals and birds. Probiotics, as defined by the
Food and Agricultural Organization of the United
Nations, are “live microorganisms which, when
administered in adequate amounts, confer a
health benefit on the host.”(1) Those in the H.
reuteri strain may stop or reduce the
overproduction of pathogens. They may also
inhibit pathogens’ production of virulence
factors. L. reuteri has been shown to be an
effective therapy in treating infantile
colic,(2) acute diarrhea,(3) rotavirus,(4)
gardnerella vaginalis(5) and alleviating the
occurrences of eczema.(6) They also show promise
in the reduction of workplace sicknesses(7) and
the suppression of infections related to H.
pylori.(8)
Scientists have been aware of L. reuteri since
early in the 20th century, when it was
mistakenly classified as a member of
Lactobacillus fermentum. Scientists began to
conduct more research on the probiotic when it
was discovered to be colonizing in animal
intestines. Unique strains of L. reuteri have
been found in the respective guts of pigs,
sheep, chickens and rodents. German
microbiologist Gerhard Reuter first isolated L.
reuteri from L. fermentum in intestinal and
fecal samples from humans during the 1960s. L.
reuteri is now considered to be an indigenous
component of some, but not all, human
gastrointestinal tracts. It is viewable on the
mucosa of the duodenum, gastric antrum, gastric
corpus and ileum.(9-10)
Walter Dobrogosz, Ivan Casas, and their fellow
researchers conducted additional studies in the
early 1980s. They discovered that L. reuteri is
able to ferment glycerol, thus resulting in the
designation of a broad-spectrum antibiotic
substance. Dobrogosz and his colleagues named
the probiotic “reuterin” in honor of Gerhard
Reuters. The discovery of its significant
properties led to more research. The existence
of L. reuteri has been found a number of foods,
including meat products and milk. In 2008, it
was established that L. reuteri’s ability to
produce reuterin in the gastrointestinal tract
enhanced its effectiveness in reducing the
growth of harmful E. coli bacteria. Reuterin’s
relative safety as an anti-microbial agent was
highlighted when it was confirmed that four to
five times the amount of reuterin would be
needed to vanquish beneficial bacteria than the
amount necessary to eliminate “bad”
bacteria.(11)
Lactobacillus Reuteri Benefits
Helps Prevent Infections
L. reuteri is a naturally occurring substance in
humans, but the probiotic is not present in all
people. Some people need daily supplements to
introduce and keep adequate levels. The L.
reuteri bacteria begin to colonize only days
after supplements are ingested. While present in
the body, the bacteria can provide strong
protection against infections and help maintain
a healthy immune system. The probiotic colonies
can shut down after ingestion has been
discontinued, so it is crucial to go on with
taking dosages of L. reuteri to achieve the
sought-after benefits.
Heals Colic
A 2006 study showed that infants given L.
reuteri as a supplement over several weeks spent
less time crying each day. Intense, sustained
periods of crying are key symptoms of colic, as
the condition is believed to cause considerable
gastrointestinal pain in babies. Colic has been
a puzzling idiopathic condition for centuries,
and babies endure the condition for weeks to
months of their early lives. L. reuteri was also
shown to have greater efficacy than simethicone,
which for years has been the traditional therapy
for colic.(12)
Treats and Prevents Diarrhea
It has been demonstrated that L. reuteri is
capable of effectively treating diarrhea,
particularly when it is a symptom of rotavirus
among children. When administered versus a
placebo, children recovered more quickly from
the illness,(13) greatly lessening the
possibility of dehydration and other dangerous
effects of rotavirus. Rotavirus is estimated to
cause the deaths of some 500,000 children under
the age of five each year. L. reuteri may also
be used as a preventive measure. Children who
receive daily doses of the probiotic while
healthy are less likely to contract diarrhea
and/or rotavirus.
Prevents and Treats Female Urogenital Tract
Infections
The RC14 strain of L. reuteri is very effective
as not just a therapy, but also a preventive
measure against yeast infections, urinary tract
infections and gardnerella vaginalis.(14) Many
women experience these uncomfortable conditions
on a chronic basis. Taking at least 10 billion
colony-forming units (cfu) per day of RC14 can
greatly improve urogenital health, reducing the
likelihood that these troublesome infections
will return.
Suppresses Occurrences of Eczema
A study conducted by a group of Swedish
scientists in 2007 shows that infants born to
eczema-prone women who ingested L. reuteri
during pregnancy were less likely to develop the
rash(15) that produces itchy, scaly skin. When
the infants in the study were given L. reuteri
immediately after birth and for the next six
months (versus a placebo), there was a
significant reduction in the number of those who
developed eczema following ingestion of the
probiotic versus those who were administered the
placebo. L. reuteri may also be an effective
treatment for children who already have eczema.
Supports Dental Health
L. reuteri destroys streptococcus mutans, which
hastens tooth decay. In tests conducted with a
number of forms of probiotic bacteria, L.
reuteri was the only species that halted the
production of S. mutans.(16) The use of chewing
gum made with L. reuteri may also help to
prevent gingivitis.(17) Inflammation of the gums
and the related symptoms of gingivitis may
subside or be eradicated completely with
products made with appropriate dosages of L.
reuteri.
May Eradicate H. Pylori Bacteria
There is limited evidence that L. reuteri may
reduce the presence the bacteria Helicobacter
pylori, which is responsible for causing peptic
ulcers.(18) This bacteria strain is also
prevalent in developing nations with sub-par
sanitation standards.
Safety of Lactobacillus Reuteri
L. Reuteri is generally well tolerated when
taken in appropriate dosages. Gastrointestinal
problems may result in some patients, and an
increase in nausea has been reported among HIV
patients.
References:
1 FAO/WHO: Health and Nutritional Properties of
Probiotics in Food including Powder Milk with
Live Lactic Acid Bacteria. Report of the Joint
Food and Agriculture Organization (FAO) of the
United Nations/World Health Organization (WHO)
Expert Consultation on Evaluation of Health and
Nutritional Properties of Probiotics in Food
Including Powder Milk with Live Lactic Acid
Bacteria.
2 Savino F, Pelle E, Palumeri E, Oggero R,
Miniero R: Lactobacillus reuteri (American Type
Culture Collection Strain 55730) versus
simethicone in the treatment of infantile colic:
a prospective randomized study. Pediatrics 2007,
119(1): 124-130.
3 Shornikova AV, Casas IA, Isolauri E, Mykkanen
H, Vesikari T: Lactobacillus reuteri as a
therapeutic agent in acute diarrhea in young
children. Journal of Pediatric
Gastroenterological Nutrition 1997, 24(4):
399-404.
4 Shornikova AV, Casas IA, Mykkanen H, Salo E,
Vesikari T: Bacteriotherapy with Lactobacillus
reuteri in rotavirus gastroenteritis. Pediatric
Infectious Disease Journal 1997, 16(12):
1103-1107.
5 Saunders S, Bocking A, Challis J, Reid G:
Effect of Lactobacillus challenge on Gardnerella
vaginalis biofilms.
Colloids Surf B Biointerfaces 2007, 55(2):
138-142.
6 Abrahamsson TR, Jakobsson T, Bottcher MF,
Fredrikson M, Jenmalm MC, Bjorksten B, Oldaeus
G: Probiotics in prevention of IgE-associated
eczema: a double-blind, randomized,
placebo-controlled trial.
Journal of Allergy and Clinical Immunology 2007,
119(5): 1174-1180.
7 Tubelius P, Stan V, Zachrisson A: Increasing
work-place healthiness with the probiotic
Lactobacillus reuteri: a randomized, double
blind, placebo-controlled study. Environmental
Health 2005, 4:25.
8 Imase K, Tanaka A, Tokunaga K, Sugano H,
Ishida H, Takahashi S: Lactobacillus reuteri
tablets suppress Helicobacter pylori infection –
a double-blind randomized placebo-controlled
cross-over clinical study.
Kansenshogaku Zasshi 2007, 81(4): 387-393.
9 Reuter G: The Lactobacillus and
Bifidobacterium microflora of the human
intestine: composition and succession.
Current Issues in Intestinal Microbiology 2001,
2(2): 43-53.
10 Valeur N, Engel P, Carbajal N, Connolly E,
Ladefoged K: Colonization and immunomodulation
by Lactobacillus reuteri ATCC 55730 in the human
gastrointestinal tract. Applied Environmental
Microbiology 2004, 70(2): 1176-1181.
11 Ivan A. Casas Walter J. Dobrogosz:
"Validation of the Probiotic Concept:
Lactobacillus reuteri Confers Broad-spectrum
Protection against Disease in Humans and
Animals," Microbial Ecology in Health and
Disease, December 1 2000, Volume 12, Number 4.
12 Savino et al.
13 Shornikova et al.
14 Reid G, et al. Oral used of Lactobacillus
rhamnosus GR-1 and L fermentum RC-14
significantly alters vaginal flora: randomized,
placebo-controlled trial in 64 healthy women.
FEMS Immunology & Medical Microbiology, Volume
35, issue 2, pages 131-134, March 2003
15 Abrahamsson et al.
16 Nikawa H, Makihira S, Fukushima H, Nishimura
H, Ozaki Y, Ishida K, Darmawan S, Hamada T, Hara
K, Matsumoto A, Takemoto T, Objectivei R.
Lactobacillus reuteri in fermented bovine milk
decreases the oral carriage of mutans
streptococci. (2004) International Journal of
Food Microbiology 95: 219-223.
17 Krasse P, Carlsson B, Dahl C, Paulsson A,
Nilsson Å, Sinkiewicz G. Decreased gum bleeding
and reduced gingivitis by the probiotic
Lactobacillus reuteri. (2006) Swedish Dental
Journal, 30:55-60.
18 Imase et al.
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